BLU-285
- Product Name
- BLU-285
- CAS No.
- 1703793-34-3
- Chemical Name
- BLU-285
- Synonyms
- Avapritinib;BLU-N;CS-2474;CPD1212;BLU-285;abaprotinib;Avapritinib(BLU-285);13C,2H3]-Avapritinib;BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285
- CBNumber
- CB13171751
- Molecular Formula
- C26H27FN10
- Formula Weight
- 498.56
- MOL File
- 1703793-34-3.mol
BLU-285 Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
- form
- A crystalline solid
- pka
- 6.96±0.10(Predicted)
- CAS DataBase Reference
- 1703793-34-3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H340May cause genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- 22985
- Product name
- BLU-285
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22985
- Product name
- BLU-285
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 22985
- Product name
- BLU-285
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 22985
- Product name
- BLU-285
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- CS-7577
- Product name
- Avapritinib
- Purity
- 99.94%
- Packaging
- 25mg
- Price
- $690
- Updated
- 2021/12/16
BLU-285 Chemical Properties,Usage,Production
Description
BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRαD842V, respectively). It is >150-fold selective for KITD816V and PDGFRαD842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC50s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KITD814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.
Uses
Avapritinib is a medication used for the treatment of tumors due to one specific rare mutation. Avapritinib is a potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor.
BLU-285 Preparation Products And Raw materials
Raw materials
Preparation Products
BLU-285 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
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- 16314854226
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- 708-557-7486
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- United States
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- (+1)-858-699-3322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
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- United States
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- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
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- +1-631-485-4226
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- 1-631-614-7828
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- +1-833-552-7181
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- +1-781-999-5354
- support@targetmol.com
- Country
- United States
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View Lastest Price from BLU-285 manufacturers
- Product
- BLU-285 1703793-34-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-24